Process Chemistry Scientist

Job Description Vertex is seeking a talented individual to join our process chemistry group in Oxford.

This role will support drug substance development programs at Vertex performing synthetic organic chemistry in the laboratory at a high level to design and execute syntheses of challenging compounds, troubleshoot a diverse range of chemistry issues and devise corrective solutions, and analyze complex data sets that leads to clear conclusion or recommendations to guide the synthetic decision.

In addition, the individual is expected to work both independently and in a matrix team environment.

Key responsibilities Designs, executes, and interprets synthetic organic experiments with a high degree of reliability, independence, and attention to detail Proficient in application and utility of a variety of analytical tools (NMR, HPLC, MS, GC and XRF) to monitor and analyze experiments Makes conceptual contributions to development activities and scientific strategies Develops novel and creative solutions to overcome synthetic and manufacturing obstacles Works as part of a cross functional development team including engineers, formulators, analysts, process safety scientists and automated synthesis specialists to deliver wider CMC aspects of projects Employs new principles and technologies Writes reports and maintains accurate records to retain and transfer intellectual property within the organisation throughout the project lifecycle Maintains compliance with the Vertex Quality Management System, ALCOA+ principles and safe working practices Performs other duties as assigned Key role-specific competencies PhD in Organic Chemistry or MSc with equivalent industrial experience Strong fundamental knowledge of synthetic chemistry Evidence of lab-based delivery and productivity Experience of working across CMC partner lines to deliver aspects of projects Demonstrated ability to solve problems, navigate adversity and ultimately deliver own part of projects Display a mindset of lifelong learning.

Be proactive towards the adoption of additional technologies and techniques Evidence of past achievement in records generation and organisation Possess excellent written and verbal communication skills Desirable additional competencies Examples of helping to advance assets or bring them to decision points, or of work that influences longer-term development Broader understanding of the life sciences industry and of the work of partner lines across the development/research interface Evidence of past contributions to social responsibility programs such as Green Chemistry or educational outreach At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends.

We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States.

Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions.

The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas.

Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East.

Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For.

For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them.

Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible.

We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.